Although you cannot change the scaling of the lotro user interface you can move things around. Here is the interface I am using:
I've tried to put all the controls and information panels at the bottom of the screen. This means the eyes don't have to move as much in the heat of battle. It also gives a nice unimpeded view of the surroundings in the top half of the screen. It took a bit of getting used to but I now prefer it to the more traditional buttons at bottom, panels at top view.
I have also tweaked up my graphics settings a bit. I am now running with high quality textures, and very high view distance for objects, landscape and frills. I do get a bit of jerkiness in towns but out in the country I get nice smooth frame rates and the visual quality is lovely. Here is a Bree screen shot (the yellow number in the corner is frames per second recorded by FRAPS):
Here is a view of the deserted Lone lands. Notice the higher frame rate:
One thing that I found makes a huge improvement in jerkiness is closing down any background programs. No more keeping a browser open in the background to view help sites. I even went through the open processes in Windows Task Manager and cleaned out some stuff I didn't need. Every little helped. My rig is an Athlon 64 3500 with 2Gb Ram running Windows XP and using a 128MB Nvidia 7300GT DDR3 graphics card.