I have meant to add Gianna Masetti's web comic "The Noob" to my links list for some time but never got around to it. Its pretty well known - I first came across it through a link from Blizzards website some time back. I'm a fan - I like the fact that it focuses on storyline rather than just a new gag every week. I find the weekly updates frustrating though - there just isn't enough in each weeks new script to satisfy. In fact I find it works better if you save it up for a few weeks and then read a whole bunch.
On the off chance that you haven't seen this before then I strongly advise going back to the start and reading it all in a couple of sittings.